microcrystalline cellulose msds fmc microcrystalline cellulose msds fmc

: CL-611NF Date Approved: 01/13/2010. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Aqueous suspensions of microcrystalline cellulose have . 1 0 obj Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. <> The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. ( It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Protect them from sunshine or rain. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. . *r_ *?~4$ &0Y# Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Molecular weight: Not Applicable 1.5. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. 8 0 obj 9,LL!z Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. ( To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. EINECS #: 232-674-9 1.7. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Superior Performance: Provides excellent water uptake and rapid swelling . Your file is uploaded and ready to be published. Alginates also function as actives in some anti-reflux products. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. MATERIAL SAFETY DATA SHEET Version: 1.0 1. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. endobj /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> <> % 102331. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? . MCC helps in the formation of spheres because of its . This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. common form is used in vitamin supplements or tablets. Truly distinctive drug delivery solutions. 4 0 obj Production of Pharmaceutical Grade Microcrystalline Cellulose. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Microcrystalline Cellulose Side Effects. ). LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. PDF (28.38 mb) 2022 Corporate Fact Sheet. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. cas:9000-11-7 msds Carboxymethyl cellulose. << SUBSTANCE IDENTIFICATION 1.1. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. It is also used in plaque assays for counting. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Molecular Weight null. We are artists at heart and creators by nature. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe It works as a moisture sponge and permits the controlled growth of spheroids. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Have an order or account question? 1 0 obj As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. B;vLZpHU%ChUyD+[ They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. There may be more fiber in your food than you realized. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. /Contents 4 0 R JFIF ` ` ZExif MM * J Q Q Q C The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. An agricultural sciences company. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. : 160182 Date Approved: 05/25/2010 Revision No. Chemical Formula: (C6H10O5)n 1.4. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. If you are already a ChemPoint customer then sign up for access to our online ordering website. Avicel RC-591 & CL-611 - Description. There have always been two different points of view for the liquidity of MCC. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Eur., JPE . METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. (1962). Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. %PDF-1.5 PDF (2.77 mb) 2021 FMC Sustainability Report. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> We can send by Fedex, by ship or by plane according to international rules. 1.3. 2 0 obj Performing this action will revert the following features to their default settings: Hooray! Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . stream ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. In large quantities it provides dietary bulk and may lead to a laxative effect. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Request media, explore upcoming events and read our latest updates. endobj No. Cellulose microcrystalline for column chromatography. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? endobj Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. ( Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, % LOT #: Available upon request. P}MFbN#[>r(y on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Fiber supplements can lessen the absorption of some . Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Instead, they obtained a stable colloidal suspension. However, it yields non-digestible fibre. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Quick Links. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. . SCMm_>x^O9l (n. CAS 9004-34-6, pH 5 - 7.5. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Origin(s): Plant/Botanical. : 5. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Microcrystalline Cellulose E460 MSDS 1. gwf;J(e0o|1p{R~P^);ao!%{0KD7. %PDF-1.4 Some substance identifiers may have been claimed confidential, or may . iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? q86@on$^X_HuH;3` SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . gac74 [#B6`Wnw7 Microcrystalline Cellulose (MCC) Manufacturing Industry. 4 0 obj <> A family of polysaccharide products that allow distinctive drug delivery solutions. Microcrystalline Cellulose; Cellulose; Functions. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Synonyms: Cellulose, Cellulose powder, Cotton linters. << It is also inert and biocompatible. Catalog Number 102331. PharmaCentral 2021 . EMCOCEL 90 M. 130. Powder becomes slippery when wet. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Created Date: 2/10/2020 8:51:41 PM . Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . 5 0 obj ChemicalBook. pH 6.0 to 8.0 . MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Thus, Avicel contributes no or very few calories to the food system. 4. q9;v80 No. %PDF-1.4 Doses up to 30 g per day appear to be . lH5JWy}DgKRR"Fs It is a white, free-flowing powder. Revision No. /MediaBox [0 0 612 792] Avicel PH-200 microcrystalline cellulose NF, Ph. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products.